Transporters in Drug Discovery 2017


Date July 31 – August 2, 2017
Time
Location The University of Rhode Island, Kingston Campus
Location 2 College of Pharmacy
Address Line 1 7 Green House Road, Room 170
Address Line 2 Ernest Mario ’63, ’66 3D Visualization Auditorium
City Kingston
State RI
Postal Code 02881
Phone Number (401) 874-5020
Contact Name Angela Slitt
Contact Email Address aslitt@uri.edu
Website http://web.uri.edu/pharmacy/cpd/drugtransporters/
Description

Several factors led to the recent emphasis on the field of transporters and their impact on drug absorption and disposition. Pharmaceutical industry continues to have keen interest in optimizing the physicochemical space of NCEs and minimizing their Cytochrome P-450 (CYP)-mediated metabolic liability. This led to the increasing selection of compounds that are both hydrophilic and polar in nature. Such chemical space inherits low passive permeability and metabolic clearance characteristics, and more importantly have potential contribution of transporters to their disposition in man. This paradigm shift presents the research community with a more difficult chemical space for addressing drug absorption and predicting pharmacokinetics and tissue distribution. Appropriate understanding of transporters and in vitro and in silico tools that characterize their contribution to drug absorption, disposition and toxicity is key for the success of the pharmaceutical industry. Additionally, the US FDA, EMA and other regulatory agencies provided new guidance on approaches to assess the liabilities of transporter-mediated drug-drug interaction (DDI), efficacy and organ toxicity for new chemical entities (NCEs) with special emphasis on certain transporters with considerable knowledge in the clinic.

 

 

Payment Information

Registration fee includes all program materials and on-site meals including continental breakfast, breaks, lunch, one on-site dinner Monday evening and one off-site dinner Tuesday evening. Paid registrants may bring a guest to dinner for an additional $50. Please select the dinner guest option during the registration process and add the name of your dinner guest in the Additional Attendee option. 

Payment via Visa, Master Card, Discover Card, or American Express can be made upon completion of this online registration.  Electronic checks are also accepted. No payments or registrations will be accepted by phone.

Questions about conference program should be directed to Associate Professor Angela Slitt, PhD at  aslitt@uri.edu or (401) 874-5020. Questions about payment and registration should be directed to Brenda Norris at (401) 874-5552.

Program Registration

Attending @ $1750
Monday Night Dinner Guest (non-registered guest)
7/31/2017
Attending @ $50
Tuesday Night Dinner Guest (non-registered guest)
8/1/2017
Attending @ $50
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